MICR3001 Lecture Notes - Lecture 7: Inactivated Vaccine, Edward Jenner, Adaptive Immune System
Document Summary
Vaccine: preparation from pathogen administered into human or animal system which stimulates a protective immune response. Inactivated vaccines: killed , produced by chemical treatment (eg. Subunit vaccines: purified single antigen or group of antigens used as a vaccine, rids sample of toxins. Dna vaccines: eukaryote expression construct containing antigen gene. Live attenuated vaccines: produced by growth of the microorganism in unusual conditions (eg. If vaccine was against respiratory infection, would want good immune response in the lung. Protects infection from occurring: sometimes, can just reduce the severity of disease. Bordetella pertussis is the causative agent of whooping cough: respiratory tract infection. 1998: 45 million cases, 400 000 deaths, even though inactivated vaccine was available, heat treated and killed with acetone, vaccine side effects, thus, purified vaccine developed. Site direction mutagenesis has been used to detoxify pertussis toxin: change toxin to toxoid.
