BMS314 Lecture Notes - Lecture 2: Cardiac Output, Vasomotor, Vasoconstriction
Interstitial Fluid Dynamics
L1 - the dynamics of tissue interstitial fluid formation
L2 - abnormalities of blood flow, and
L3 - abnormalities of haemostasis.
Body Fluid:
Normal
~60% of lean body weight= water
2/3 intracellular, 1/3 extracellular
Abnormal
↓ ECF = DEHYDRATION
Excess extracellular fluid = OEDEMA/ EFFUSION
Fluid in tissues= oedema;
Fluid in body cavities= effusion
Oedema and Effusions
Categorised according to content and location:
Transudates and Exudates
A general guide to Exudate and Transudate classification
Sp. G = specific gravity
LEARN! + numbers
Question will be to categorise effusion with this table
Modified transudate is between exudate and transudate (mid-range category)
Transudate - little bit leaky (watery fluid)--> Exudate - very leaky (more cells and larger proteins)
• Sub Cutaneous Oedema
• Generalised = Anasarca
• Recognising oedema in soft tissue is via Pitting Oedema
• Pitting Oedema
• Lymphatic vessel, clear fluid in spaces
• Dermal Oedema
Document Summary
L1 - the dynamics of tissue interstitial fluid formation. A general guide to exudate and transudate classification. Question will be to categorise effusion with this table. Modified transudate is between exudate and transudate (mid-range category) Transudate - little bit leaky (watery fluid)--> exudate - very leaky (more cells and larger proteins) Sub cutaneous oedema: generalised = anasarca, recognising oedema in soft tissue is via pitting oedema, pitting oedema. Increases intravascular pressure can cause fluid to leak out. Lymphatics are the bodies drainage system, therefore if it gets blocked, fluid will accumulate. Decreased blood oncotic pressure can cause fluid to escape the blood vessel, as there is no osmotic hold and thus fluid will move to the higher osmotic pressure. Increased vascular permeability, this can cause fluid to ooze out. Sites of oedema formation: cause, gravity, tissue tension - tight skin with low interstitial space is less likely to get fluid accumulation.
