PSY2061 Lecture Notes - Lecture 9: Nucleus Accumbens, Impulsivity, Reward System
5 Jun 2018
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PSY2061 – Week 9 – Lecture
• psychopharmacology
•
o how a drug works can be described according to two key
processes
o
▪ pharmacokinetics - what the body does to the drug
▪
▪ administration
▪
▪ oral
▪ intranasal - snorting
▪ inhalation - gases and smoke
▪ injection
▪ sublingual/buccal
▪
▪ placing the drug under the tongue,
gum, cheek, teeth
▪ transdermal
▪
▪ placed and absorbed through the skin
▪ absorption
▪
▪ rate at which the drug enters the blood
stream
▪ oral - slow absorption, unpredictable
potency
▪ lungs- most rapid, maximum potency -
bypasses the liver
▪ injection - rapid, some loss of potency
▪ distribution
▪
▪ delivery of the drug to organs in the body
▪ only a small portion of the drug actually
interacts with brain
▪ depends on blood flow and solubility
▪ water soluble vs fat soluble drugs
▪
▪ water soluble - harder to cross the
blood brain barrier
▪ drug dose specified in terms of mg of drug
per kg of body weight
▪ blood brain barrier
▪
▪ pass across BBB depends on lipophilicty,
electrostatic charge, molecular size, active
transport
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