PHY2011 Lecture Notes - Lecture 9: Conformational Change, Resting Potential, Retinoid

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20 Jun 2018

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Week 3 L3 (T3L1) -Cell Communication in Defence

Types of signalling

oElectrical -use flow of current

oChemical -use chemical agents

oBoth can occur in synaptic or non-synaptic regions, and while neurons can undergo

all four types, non-neuronal cells can only do three, as synaptic chemical signalling is

unique to neurons

Synaptic signalling

oRequire specialised structures between cells

Separated by fluid filled gap

Gap is bridged by channels (hemi channel provided by each cell)

^Gap junction – prevents leaking

oElectrical synaptic signalling

Very fast -no delay in information transfer

Activity in a group of cells well synchronised -ie in the heart/gut

Two things required for chemical signalling

oChemicals (Ligands, agonists etc)

oReceptors -to recognise chemicals

oReceptors are important, as they dictate what happens, chemicals can bind to a

variety of different receptors and have different effects

Chemicals

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