PHA2022 Lecture Notes - Lecture 1: Laxative, Magnesium Citrate, Receptor Antagonist
15 Nov 2018
School
Department
Course
Professor
Document Summary
Ida: define the terms pharmacodynamics and pharmacokinetics. Ans: pharmacodynamics: what the drug does to the body. Pharmacokinetics: what the body does to the drugs. It is the movement of the drug into and out of the body: discuss examples of non- specific ways in which drugs can produce therapeutic effects. Ans: mylanta: contains magnesium hydroxide to neutralize stomach acid. 2h: chelating agents: remove heavy metal ions in cases of poisoning or disorders, for example edta (ethylenediaminetetraacetic acid). Osmotic agents: alter fluid balance between body compartments. Ans: selectivity depends on chemical structure, molecular size, and electrical charge. individual classes of drug bind only to certain targets and individual targets recognize only certain classes of drug. Selectivity is relative meaning it may be related to dose or concentration. Increase in dose => increase chance of interacting with other targets: explain the terms potency, affinity and efficacy and use these to compare and contrast full agonists, partial agonists and antagonists.
