PHA3801 Lecture Notes - Lecture 21: Timolol, Glucocorticoid, Esmolol
24 Jul 2018
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Adrenoceptor antagonists: alpha- and beta-adrenoceptor antagontists prevents action of na/a. Adrenergic neurone blockers: block na release from sympathetic nerves. Adrenoceptor subtpyes: classified as alpha or beta based on: Drugs can be a/b-receptor specific. a-adrenoceptor subtypes: into a1 + a2 subtypes based on their sensitivities to particular ant- A1 primarily at post-junctional sites smcs. A2 mostly on sympathetic nerve endings activation inhibits na release, -ve feedback loops. b-adrenoceptor subtypes: B1 abundance in heart + intestinal tract inc hr + force. B2 abundance in respiratory tract, bv"s and liver relaxation of airway and vascular sm, glycogenolysis/glucogenolysis in liver. B3 relatively small numbers in fat cells + heart potential targets for anti-obesity medications. Adrenoceptor agonists: the direct effects of a given adrenoceptor agonist on an effector cell depends on: Receptor selectivity of drug alpha vs beta receptors, and subtypes. Cellular response to receptor activation stimulation of b2 receptors in airway sm results in relaxation (bronchodilation)
