PHA3801 Lecture Notes - Lecture 16: Heparin, Microcephaly, Salbutamol

• School: Monash University
• Department: Science - Pharmacology
• Course: PHA3801
• Professor: All

Document Summary

Variability: if not taken into account lack of efficacy or unexpected side-effects age, genetic factors, immunological factors, pathological states (kidney/liver), drug interactions (1). Distribution: apparent volume of distribution (protein binding, bbb) Volume of distribution: more body water and less body fat vs adults. Increased vd for water soluble drugs, dec for lipid soluble drugs. 6-12 months: clarke"s sa use body sa calculation using a nomogram. Maintenance dose: = sa [m2] x adult / 1. 73m2. Excretion: dec drug therapy = start low, go slow. Volume of distribution: (dec) inc body fat, dec lean body mass and water, reduced plasma [albumin]. Metabolism: (dec) dec hepatic metabolism and blood flow, dec liver mass, prolonged life of drug. Excretion: (dec) dec renal function and drug excretion. Target organ sensitivity dec: altered receptor function (e. g. impairment of cholinergic and adrenergic function), dec receptor density and affinity.