NUT2103 Lecture Notes - Isozyme, Reabsorption, Getting Out

• School: Monash University
• Department: Health Sciences - Nutrition
• Course: NUT2103
• Professor: Aimee Dordevic

Document Summary

Therapeutic range of drug plasma concentration achieved. => administration route / starting dose / drug administration frequency. Explain the advantages and disadvantages of different routes of administration. Explain the factors affecting the movement of drug into, around and out of the body: oral bio-availability. Drug: ph / pka, size, susceptibility [ gut & liver enzymes breakdown ] Patients: food presence & type, influence drug absorption, gastric motility, blood flow, distribution around body. Efficacy of delivery to tissues: particular regions" blood flow. Held within tissues: bind to extra-vascular sites. = drug appears to be distributed [concentration = plasma"s : > compartments distributed = < plasma"s, vol. Elimination: re-distribution via circulation [removed action site, brain => (lower resting blood flow)tissues [re-distribution] = intra-venous sedative"s effects : cleared from plasma, kidneys. Metabolism: intra-cellular, kidney, intestine, liphophilic drugs [crosses plasma membrane, liver, oral absorption, portal circulation, lipid-soluble => h2o-soluble, excretion [kidneys, catabolic, oxidation/ reduction/ hydrolysis = >polarity [ionizable group added]