NUR5011 Lecture Notes - Lecture 1: Cirrhosis, Insulin Receptor, Steroid Hormone Receptor
3 Jun 2020
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Document Summary
Identify essential parts of a medication order: list seven essential steps to follow when administering medication. Identify physiological factors and individual variables affecting medication action: state systems of measurement that are used in the administration of medication, demonstrate accurately basic drug calculation to ensure safe administration of medications. Factors affecting drug absorption: rate of dissolution, surface area, blood flow, lipid solubility, ph partitioning. Having entered bloodstream, some free drug molecules bind to proteins forming drug-protein complexes. Some drugs bind highly e. g. warfarin, some in bound state, drug does not exert an effect. Needs to be free to work as the drug. Lipid-soluble drugs have high affinity for the adipose tissue so they can accumulate. Sometimes adipose tissue acts as reservoir for the drug, releasing it slowly back into the bloodstream. Chemical reactions cause more water-soluble metabolites by specific drug metabolising enzymes. Metabolite from phase one joins with a polar substance, increasing water- solubility and enhancing excretion.
