IMM2011 Lecture Notes - Lecture 1: Myeloid Tissue, Cell Adhesion Molecule, Phagocytosis
9 Jun 2018
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LECTURE 2:Cells of the immune system
Learning objective 1:Name and provide basic description of the 3 broad “layers” of
Immunity
Physical barriers: which consist of structures to keep the pathogen out , for instance skin
Innate immunity: consist of a series of cells and soluble molecules that respond
immediately upon an infection .
Adaptive immunity: provides long lasting immunity and remembers the pathogen through
memory cells incase it comes back .
ability to generate a response that can deal with future encounters (adaptive immunity
Learning objective 2:basic lineage structure associated with the cells of the
immune system
- All blood cells are generated in the bone marrow
- Basic lineage is from hematopoietic stem cells which is found in the bone marrow.
- Hsc develops into other cell types can renew it self.
- HSC is then divided into three different lineages.
1) Dendritic cell: singalling cell
2) Lymphoid lineage: which is broken into natural killer cells , T and B lymphocytes
3) Myeloid progenitor: which generate the granulocytes - from this we get
megakaryocytes (platelet) ,erythrocytes (RBC) , mast cells and myeloblast
Then from the myeloblast: we give rise to basophil , neutrophil , eosinophil and monocytes
Document Summary
Learning objective 1:name and provide basic description of the 3 broad layers of. Physical barriers: which consist of structures to keep the pathogen out , for instance skin. Innate immunity: consist of a series of cells and soluble molecules that respond immediately upon an infection . Adaptive immunity: p rovides long lasting immunity and remembers the pathogen through memory cells incase it comes back . ability to generate a response that can deal with future encounters (adaptive immunity. Learning objective 2:basic lineage structure associated with the cells of the immune system. All blood cells are generated in the bone marrow. Basic lineage is from hematopoietic stem cells which is found in the bone marrow. Hsc develops into other cell types can renew it self. Then from the myeloblast: we give rise to basophil , neutrophil , eosinophil and monocytes. Learning objective 3: give a basic definition of the 6 white blood cells described today: macrophage/monocyte.
