BMS2062 Lecture Notes - Lecture 11: Membrane Protein, Ribosomal Rna, Iron
30 May 2018
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Week 6. Protein folding and Protein families
FROM MRNA TO FUNCTIONAL PROTEIN: PROTEIN FOLDING
• Anfinsen experiments 1
• Anfinsen experiments 2
o Re-oxidation of reduced denatured protein under denaturing conditions
= ~1% activity of native enzyme
o In absence of reducing agent – cysteines can form disulphide bonds
• Anfinsen experiments 3
o Re-oxidation of reduced denatured protein under native conditions
= ~100% activity of native enzyme
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