BMS2062 Lecture Notes - Lecture 14: Mutation, Red Blood Cell, Immunoprecipitation
30 May 2018
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Week 7. What do Inflammation, HIV and Malaria have
in common?
• Eosinophils can undergo degranulation and its products can interact with smooth muscle cells of
airways and cause constriction -> asthma
• Focusing on interactions with chemokine and chemokine receptors on leukocytes
• Chemokine receptors
o G protein-coupled receptors
o 7 transmembrane helical regions – sequences that are highly hydrophobic
o N terminal end is on the outside of the cell
o Carboxyl terminal is on the inside
o 3 loops connecting outside and inside
o At least 3 kids of traslatioal odificatios”
1. Disulphide bonds (3)
2. Glycosylation – N (asp_ or O (ser or thr) link – addition of sugar group to protein
3. Tyrosine sulfation – at N terminal extracellular region
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