BMS1011 Lecture 1: Week 10 OXIDATION

• School: Monash University
• Department: Health Sciences - BMS
• Course: BMS1011
• Professor: Dr Nirma Samarawickrema

Document Summary

Lecture 18 (c6 etc) & 19 (c7 oxidative phosphorylation) Four ways of electron transfer: directly as electrons. H- has 2 electrons: direct combination with oxygen. Discuss the concepts of e-transfer in biological oxidation processes: dependent upon redox potentials. E- transfer from donor to acceptor depends on relative affinity of electron acceptor for the electrons: measure of the affinity is: redox potential (e0) in volts. Free energy exchange is proportionate to ability of reactants to donate or accept electrons. Explain how reduced co-factors (nadh & fadh2) are high energy sources. Describe the features and components of the etc. Cytochrome c is not part of an enzyme complex because it moves between complex iii and iv as a free soluble protein. Two e- removed from nadh and transferred to ubiquinone (q) Energy produced pumps 4h+ to intermembrane space (2 from qh2 and 2 from matrix) Energy from the transfer of electrons down the etc used to establish a protein gradient ph gradient.