BMS2021 Lecture Notes - Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cell, Cfu-Gemm

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Blood contains many types of cells with different function, all derived from one cell of origin (stem cells) in the bone marrow. Red cell: the main function is to transport oxygen and delivery of 02 to tissues. White cell: fight infection and mediate the immune response. 3 types recognised on the basis of morphology and chemistry and function. Neutrophils: multilobed nucleus most common the function to phagocytose bacteria. Basophils: function is to secrete histamine and mediate inflammatory reaction they are the circulating form of tissue mast cells. T cells kill virus infected cells and regulate the activity of other cells. Nk cells subset of lymphocytes that kill some types of tumour cells and also some virus infected cells. Bone marrow is the site of blood cell formation from hematopoietic stem cells. Bone marrow can be harvested and can be transplanted into recipient without marrow.

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