PSYC20006 Lecture Notes - Fall 2017 Lecture 12 - Nootropic, Dementia, Design of experiments
20 Sep 2018
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Document Summary
A major neurotransmitter of the central and peripheral nervous system. Made from choline (derived from the breakdown of lipids) and acetate (aka acetic acids) Two main receptor types nicotinic and muscarinic: nicotinic receptor. In the peripheral nervous system muscle fibres must be able to contract rapidly so they contain rapid, ionotropic nicotinic receptors: muscarinic receptor, metabotropic (g-protein coupled, stimulated by muscarine. In the central nervous system both nicotinic and muscarinic receptors exist but muscarinic receptors predominate. Ach in the periphery controls muscle contraction. In the pns, ach is the primary neurotransmitter that acts on nicotinic receptors at the neuromuscular junction: ach transits signals from the motor neuron and causes muscles to contract -> controls muscle movement. Botulinium toxin is produced by bacteria that grows in canned food (most acutely lethal toxin known) -> causes death by paralysing respiratory muscles -> works by preventing the release of.
