PSYC20006 Lecture Notes - Lecture 12: Metabotropic Glutamate Receptor, Kainate Receptor, Ampa Receptor
Document Summary
Lecture 12 (w6): glutamate & gaba inhibition & excitation. Glutamate & gaba: both believed to be first to evolve, found in very simple organisms, most common nts in cns, act as true" nt, directly affect likelihood of post-synaptic neuron firing. In most long projection neurons: connections are point-to-point, many region-specific functions. Glutamate receptors: 4 major types, 3 are ion channels (ionotropic, nmda receptor, ampa receptor, kainate receptor, 1 is g-protein coupled (metabotropic, metabotropic glutamate receptor. Inhibitory networks reduce likelihood neurons fire for non-preferential stimuli: synthesis, produced from glutamic acid, glutamate converted into gaba then gaba back to glutamate, 2 types gaba receptors, gabaa receptors: ion channels, gabab receptors: g-protein coupled. Gaba + seizure disorders: relatively common, ~400,000 in aus, seizure: sudden excessive neuron activity, can cause muscle convulsion, epilepsy: neurological disorder characterised by seizures, caused by abnormality of gaba neurons and/or gaba receptors.