PHYS20008 Lecture Notes - Lecture 24: Distal Convoluted Tubule, Proximal Tubule, Electrochemical Gradient
21 Jul 2019
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Lecture 24: renal function: tubular function 7/05/19 clearance rate: 300ml/min. Appears at 12mg/min -> 12mg lives in 300ml of plasma. Reabsorption or secretion? reabsorption filter 200l of plasma per day don"t pee it all out (pee 2l per day so reabsorption is important) Proximal tubule: coming out of glomerulus, blood coming out of glomerulus is sludgy/thick/viscous left with albumin and rbcs, bulk of water + sodium that will be reabsorbed needs to be absorbed as soon as possible. What is the most important solute reabsorbed? sodium cant absorb anything else without reabsorption of sodium. Active transport -> passive transport cascade (secondary active transport dependent on reabsorption of sodium: na+ is reabsorbed by active transport (sodium-potassium pump pumps sodium out of the cell) Highest concentration of pumps on the basolateral surface pumps na+ out into ecf. Need sodium channel to bring it right through the cell: electrochemical gradient drives anion reabsorption.
