GENE20001 Lecture Notes - Lecture 30: Allele Frequency, List Of Bus Routes In Queens, Mutation Rate
Document Summary
Previous consideration of mutation assumed that all genotypes are equally fit. Not a good assumption if this mutation is coding region. Most new coding region mutations do have an impact on fitness. For deleterious alleles (with respect to fitness) selection and mutation oppose each other, a low equilibrium allele frequency is maintained. Mutation produces a deleterious allele and selection selects against it. In a large drosophila population, the fitness of a recessive phenotype is calculated to be. 0. 80, and the mutation rate to the recessive allele is 4 10-6. Gene a is responsible for a deleterious autosomal dominant disorder. The frequency of affected (aa) individuals is 4. 0 x 10-6. The reproductive capacity of these individuals is about 10% of that of normal individuals. Estimate the rate at which a mutates to the deleterious a allele. Freq of aa = 2pq (approx. ) since this population not that far out of hw. Assume: there is such strong selection against a.
