CHEM10006 Lecture Notes - Lecture 14: Acid Dissociation Constant, Zwitterion, Ion

• School: University of Melbourne
• Department: Chemistry
• Course: CHEM10006
• Professor: Frances Separovic

Document Summary

Buffer solutions, h-h equation, amino acids and ph ionization. A buffered solution is one that prevents large changes in ph when either oh- ions or h+ ions are added. E. g. blood (because the ph scale is logarithmic, a small change in ph has a big effect), sea water. A good buffer will have close to equal proportions of the acid and its conjugate base. The buffer is restricted by how much acid or base is added. If acid or base is weak, assume x is negligible. A buffer may be formed by mixing a weak acid with its conjugate base, Or, a strong base to neutralise half the weak acid = 50/50 mixture of acid and its conjugate base. Used to determine the ph of a buffer solution. Also used to figure out the proportion of charged and uncharged states of a drug, as this influences uptake and distribution metabolism and receptor binding. (cid:2198)=(cid:2198)+(cid:2197)[ ](cid:2196)