BIOM30002 Lecture 11: 10-12 HIV-1 infection virology, pathogenesis and treatment B
Document Summary
Tissue (particularly git): massive early decline and never really returns to normal. This graph links cd4 t cell count to diseases contracted as hiv progresses. Intermediate phase: tb (a coinfection) is most common & most important disease that occurs with hiv. Advanced (cd4<200): opportunistic infections, some unique to hiv, rare cancers. Immunology: immune defects in people infected with hiv. Hiv attacks cd4+ t cell homeostatic pathway all along the way to deplete cd4+ t cells by destroying them, and impairing production of t cells. Destroys many more tc in git than blood. Syncytium formation: infected t cell will have gp120 on surface. Lymph node fibrosis: ln needs the right cytokines like il-7 to keep t cells alive and proliferating. This process causes ln to lose these signals. Some people progress with hiv with varying degrees. Nef deleted virus limits t-cells loss - become long term non-progressors. Co-infection with other viruses eg. , cmv (speeds up), gbv-c (slows down)
