BIOM30002 Lecture Notes - Lecture 34: Amyloid Precursor Protein Secretase, Neurodegeneration, Lrp1
27 Jul 2018
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Described by alois alzheimer in 1906, first patient was auguste deter. Symptoms: age 51 with first symptoms, died at 56, forgot her (cid:374)a(cid:373)e a(cid:374)d her hus(cid:271)a(cid:374)d"s name, forgot the name of common objects, transformed personality (jealousy towards her husband) One in four people over the age of 85 have dementia. An estimated 413,106 australians currently live with dementia. Clock drawing test people (cid:449)ith de(cid:373)e(cid:374)tia do(cid:374)"t k(cid:374)o(cid:449) (cid:449)here to put (cid:374)u(cid:373)(cid:271)ers. Prodromal period (up to 5 years) = decline in cognition characterised by. Impairment in short-term memory and possible impairments of working memory: usually precedes the formal diagnosis of ad. Impairment (mci) noticeable cognitive defects but not as serious as ad and some go on to develop ad. Cell loss is a common feature in the pathology of age-related (cid:374)eurodege(cid:374)erati(cid:448)e disease e. g. alzhei(cid:373)er"s, parki(cid:374)so(cid:374)"s, hu(cid:374)ti(cid:374)gto(cid:374)"s. Tau is part of the cytoskeleton interacts with tubulin to stabilise microtubules and regular axonal transport.
