BIOL10005 Lecture Notes - Lecture 15: Phenylalanine, Sickle-Cell Disease, Missense Mutation

• School: University of Melbourne
• Department: Biology
• Course: BIOL10005
• Professor: Dawn Gleeson

Document Summary

* mutations are any alteration in dna sequence from a single base pair substitution, deletion, insertion or several base pairs or a major alteration in the structure of a chromosome. * mutations can be somatic (e. g. many cancers such as melanoma) and germ line (gamete e. g. * mutations can be somatic (e. g. many cancers such as melanoma) and germ line (gamete e. g. sperm or egg will be transferred to next generation) (e. g. * mutations can be somatic (e. g. many cancers such as melanoma) and germ line (gamete e. g. sperm or egg will be transferred to next generation) (e. g. bent ear cat) * mutations can also be spontaneous (with no apparent reason) or induced (environmental situation where something in environment acts as mutagen e. g. japa(cid:374)"s (cid:374)u(cid:272)lear (cid:373)eltdow(cid:374)(cid:895) * chromosomal mutations are gross mutations deletions translocations involve many genes if visible under a light microscope 4mb approx. *mutations can occur in coding (2% dna) and non-coding regions (98% dna) of the genome.