BCMB20002 Lecture Notes - Lecture 3: Modular Arithmetic, Amide, Histidine

• School: University of Melbourne
• Department: Biochemistry and Molecular Biology
• Course: BCMB20002
• Professor: Terry Mulhern

Document Summary

Acidic residue(when the carboxylate get protonated become deionised) Basic (acidified the solution and become positively charged) Double can be shared to the two nh (partial bond character) Perfect shape to orientate towards forming hydrogen bonds with bases in. The double bonds can be shared in the 5 membered ring. Hydrogen can be move back and forth. H can be stabilised on histidine ring. Histidine can exist as 3 totemes, both h are protonatedand 1 h is stably protonated. Can ligate metal (structural stabilising and ligation) Nh = 1 because it is heavier than carbon. Transfer the gamma phosphate group onto the oxygen (serine) Neutral hydrophilic group ->extreme negatively charged reactive group. Phosphorylation is important for the regulation and amplification of many biological processes. It changes the chemical nature of the residue, polar/neutral to polar/negatively charged. Build the hydrophobic core, give stability of the protein. On beta carbon(chiral), there are methyl group,methylene. 6 membered ring and a 5 membered ring.