BCMB20002 Lecture Notes - Lecture 8: Neurodegeneration, Oligomer, Skeletal Muscle
Document Summary
Hemoglobin consists of 2 a and 2 b subunits. Oligomer- multimeric protein consisting of a small number of subunits. Monomer (no quaternary) (homo) dimer, trimer, tetramer. Hemoglobin is a tetramer or a dimer of 2 ab protomers. Protomer- structural unit of a protein with quaternary structure. Each subunit can be divided into domains. Immunoglobulins have 4 subunits: 2 heavy, 2 light chains. The variable regions at end of each chain change when they bind antigen each ellipse is a domain. The chains come together to form the binding site. Be able to talk about each level of structure from a diagram. If one subunit changes, the whole complex can change. Multimeric proteins allow to link sites for enzyme-substrate. Oxygen storage in cytoplasm of muscle cells. 8 a helices of 7-23 aa residues. Storage and release of oxygen when rapidly contracting muscle. Oxygen binds reversibly to the fe2+ of the heme prosthetic group.