BCMB20002 Lecture Notes - Lecture 1: Gibbs Free Energy, Thermodynamic Equilibrium, Thermodynamics

• School: University of Melbourne
• Department: Biochemistry and Molecular Biology
• Course: BCMB20002
• Professor: Terry Mulhern

Document Summary

Gibbs free energy is the energy of the reaction available to do work (cid:862)a(cid:448)aila(cid:271)le(cid:863) e(cid:374)erg(cid:455). Entropy is temperature (k, hence always positive) dependent. Hence for spontaneous reactions, to go forward negative deltag, have a big positive deltas (multiplied to negative t, hence more disorder), or a big negative deltah. Exergonic: deltag is negative: free energy released; favourable; spontaneous. Endergonic: deltag is positive; free energy absorbed; unfavourable; not spontaneous. Entropy important for life and biochemical reactions, e. g. formation of proteins. Keq is the thermodynamic equilibrium constant for the reaction. This is the relative concentrations of components at equilibrium. Equilibrium = deltag is 0 deltag is the actual free energy change for the reaction. The further away from equilibrium you start, the more work is done before you get there. Use of standard conditions allow free energy changes to be easily compared. Chemistry and physics have very general standard conditio(cid:374)s, (cid:862)1m e(cid:448)er(cid:455)thi(cid:374)g(cid:863): 298.