MD 1010:12 Lecture 8: Linking Reaction Summary

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orangegerbil776

10 Jun 2018

School

James Cook University

Department

Course

MD 1010:12

Professor

MTC

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pyruvate

00000000 00000000

'dad'd

.IO#@IHqt.KdHd*pyruvateNAD+

Thiamine lipoate

(OASH

(Oz §FAD

pyruvate dehydrogenase

NADHZ complex .

acetyl CoA

pyruvate +Wehzyme A +NAD ~(02 tAcetyl (OA tNADHZ

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Related Questions

Please Help me with these! I think 55 is D, 57 is A or E...and 64 B or E....I am not sure. Please verify! Thanks!

1. Choose the TWO correct statements describing the citrate cycle.

	ATP is an indirect product of the citric acid cycle
	Acetyl CoA can increase the pool of citric acid cycle intermediates
	Fatty acids can increase the pool of citric acid cycle intermediates
	ADP inhibits Î±-ketoglutarate dehydrogenase
	The pool of mitochondrial oxaloacetate can be increased by pyruvate
	All enzymes of the citric acid cycle are found soluble and free in the mitochondrial matrix

2.Which molecule in the net reaction of the citrate cycle contributes to the inhibition of pyruvate dehydrogenase?

	NADH
	H⁺
	H₂O
	FAD

3. How would a high NADH to NAD⁺ ratio be expected to affect the pyruvate dehydrogenase reaction?

	The E1 subunit is phosphorylated by pyruvate dehydrogenase kinase, and the catalytic activity of pyruvate dehydrogenase decreases.
	The last step of the pyruvate dehydrogenase reaction is blocked, resulting in a decrease in activity.
	The pyruvate dehydrogenase phosphatase-1 enzyme would increase, resulting in pyruvate dehydrogenase activation at an accelerated rate.
	The pyruvate dehydrogenase kinase enzyme activity would increase, resulting in an increase in pyruvate dehydrogenase activity.

After glycolysis and before the citric acid cycle (TCA), the pyruvate dehydrogenase complex breaks down the pyruvate to three separate components; a carboxyl group, a two-carbon fragment, and coenzyme A (CoA). What happens next to these products?

a. The carboxyl group is reduced and released as CO2, the two-carbon fragment is used to reduce NADH, and CoA is converted to acetyl CoA for the TCA.

b. The carboxyl group is oxidized and released as CO2, the two-carbon fragment is used to oxidize NAD+, and CoA is converted to acetyl CoA for glycolysis.

c. The carboxyl group is used to reduce NAD+, the two-carbon fragment is oxidized and released as CO2, and CoA is oxidized to acetyl CoA for oxidative phosphorylation the TCA.

d. The carboxyl group is oxidized and released as CO2, the two-carbon fragment is used to reduce NAD+, and CoA is converted to acetyl CoA for the TCA.

e. The carboxyl group is used to oxidize NAD+, the two-carbon fragment is reduced and released as CO2, and CoA enters the TCA.

MD 1010:12 Lecture 8: Linking Reaction Summary

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