MMED1005 Lecture Notes - Lecture 15: Autocrine Signalling, Insulin Resistance, Anterior Pituitary

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sBONE AND BLOOD CALCIUM
Parathyroid glands:
- Produce parathyroid hormone
- Calcitonin is not released from the parathyroid but released from the C cells of the
thyroid gland
- Parathyroid hormone: stimulates the breakdown of the resorption of bone
o Side effect: releases calcium into the blood
o When there is a shortage of calcium, calcium is taken from bones
- Calcitonin: stimulates the growth of bone using calcium from blood
- *no need to know the parts of bone in the above diagram
- What stimulates the release of calcitonin and parathyroid hormone (PTH)?
High plasma calcium
Stimulates parathyroid
glands to release PTH
Inhibits thyroid C cells
Increases plasma calcium
Low plasma calcium
Stimulates thyroid C cells to
release calcitonin
Inhibits parathyroid glands
Decreases plasma calcium
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Within bone, the two main types of cells are osteoclast (break down bone) and osteoblasts
(make bone). Calcified matrix is where the calcium is used.
How does osteoclast break down bone? Releasing acids
- *No need to learn all the details in above diagrams
Growth hormone increases the size of bone. Growth hormone site
of action within bone is the epiphyseal growth plate where the
insertion of new bone material occurs.
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Document Summary

Calcitonin is not released from the parathyroid but released from the c cells of the thyroid gland. Parathyroid hormone: stimulates the breakdown of the resorption of bone: side effect: releases calcium into the blood, when there is a shortage of calcium, calcium is taken from bones. Calcitonin: stimulates the growth of bone using calcium from blood. *no need to know the parts of bone in the above diagram. Within bone, the two main types of cells are osteoclast (break down bone) and osteoblasts (make bone). Calcified matrix is where the calcium is used. *no need to learn all the details in above diagrams. Growth hormone site of action within bone is the epiphyseal growth plate where the insertion of new bone material occurs. When blood glucose increases (e. g. after a meal) Brings blood glucose back down e. g. through acting on the liver to increase glycogen synthesis and fuel storage (e. g. glucose) Causes fuels to be liberated from their stores.

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