EHR523 Lecture Notes - Lecture 11: Inflammatory Bowel Disease, Colorectal Cancer, Sigmoid Colon
Document Summary
86% of diagnoses are in people >55 yrs. 1 in 13 people will be diagnosed by 85 years. Anatomy of the large intestine: part of the digestive system about 1. 5m in length that receives digested food materials from small intestine, consists of 5 parts, function of the colon is to: Processes waste products and prepare for its elimination: function of the rectum is to store and evacuate waste. Pathophysiology of colon cancer: colon cancer is usually an adenocarcinoma, cancer potentially occur in any section, most common sites for colon cancer are: Layers of the colon wall: colon wall consists of 4 layers: Risk factors of colon cancer: age: incidence mostly occurs >55 yrs, family history: first degree relative with colon cancer or polyps, lifestyle: Obesity (50% and 20% higher risk in men and women). Diets high red meat and animal fats. Crohn"s disease, ulcerative colitis, etc. : type 2 diabetes: 27% higher risk than non-t2d: high alcohol:
