BIOL3108 Lecture Notes - Lecture 26: Natural Killer Cell, Adaptive Immune System, Antigen-Presenting Cell
Document Summary
Lecture 26: crowd control - tumour immunology 1. Generates immunological memory that can prevent re-infection by the same microorganism. Comparing an immune response in infection and cancer. The immune system recognises and defends against infectious agents, such as bacteria, viruses and fungi. Dendritic cells: present pathogen-associated antigens to t cells. Natural killer (nk) cells and cytotoxic t cells: kill virus-infected cells. Antibodies (aka immunoglobulins): neutralise infectious agents and mediate opsonisation. Opsonisation -> makes the antibody more "tasty" to t-cell. The immune system recognises and defends against cancers cells. Dendritic cells: present tumour-associated antigens to t cells. Natural killer (nk) cells and cytotoxic t cells: kill cancer cells. Antibodies: induce antibody-dependent cell-mediated cytotoxicity (adcc) on cancer cells. Many of the mechanisms used by the immune system to recognise and eliminate infectious agents may also be used to launch attacks against cancer cells. Dendritic cells -> bridge between the innate and adaptive immunity systems.
