KIN 324K Chapter Notes - Chapter 7: Monocyte, Complement System, Eosinophil
22 Dec 2016
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-stored in the liver attached to ferritin and hemosiderin. Rh- - no surface antigen d no anti-d antibodies unless exposed sensitization events - miscarriage placental tearing birth hemolytic disease of the newborn - -attacks child"s blood supply. Occurs only if mother is rh- and child is rh+ Physiological responses adaptive immunity - delayed response to specific antigen. Specific t-cells and b-cells respond to different foreign substances we are exposed to during our lifetimes. Process begins immediately but may take several days to be effective phagocytic cells - neutrophils and macrophages phagocytic cells. -engulf unwanted substances like infectious agents and cellular debris. Phagosome contains unwanted substance and merges with lysosome to form a phagolysosome. Mac allows for the influx of fluid which causes lysis classical pathway - complement binds to antibody-bound foreign substances. Transported to liver and spleen where macrophages strip off complex. Mhc class i - cd8 cells bind to foreign antigen shoot perforin and granzymes to destroy infected cell.
