CHEM 118 Chapter Notes - Chapter 1: Autacoid, Neuromuscular Junction, Receptor Antagonist
20 Jan 2017
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Document Summary
Receptors can be a membrane protein, a cytoplasmic or extracellular enzyme, or a nucleic acid. Generalized: molecules that are essential to a cell"s normal biological function or replication (enzymes, dna, lipids) Specialized: biological molecules that are specifically used to intercellular communication (ion channels and proteins in membrane), designed to delect chemical signals and initiate a cellular response via activation of signal transduction pathways. Responds to neurotransmitters, hormones, cytokines, and autocoids and convey info to the cell, resulting in altered cellular response. Primary target of most drugs in clinical use. Drug receptors mush have molecular domains that are spatiallly and energetically favorable for binding specific drug molecules. Receptors interact with drugs through different chemical bonds. Covalent bonds are classified as irreversible, ionic bonds are strong but may be reversed through change in ph. Agonists bind to the receptor and activate it, like key fitting into lock and turning it.
