BILD 1 Chapter Notes - Chapter 12: Sister Chromatids, Mendelian Inheritance, Genetic Linkage

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Chromosome theory of inheritance: mendelian genes have specific loci along chromosomes and those chromosomes undergo segregation and independent assortment. Wild type: the phenotype for a character most commonly observed in natural populations. Mutant phenotypes: traits that are alternatives to the wild type due to alleles assumed to have originated as changes in the wild type. Some phenotypes have a correlation to sex. Sex-linked gene: a gene located on either sex chromosomes. X-linked genes: human x chromosome contains approx. Y-linked genes: passed along from a father to all his sons. Duchenne muscular dystrophy: x-linked disorder affects one out of 3,500 males, progressive weakening of the muscles and loss of coordination; absence of dystrophin (key muscle protein) Hemophilia: an x-linked recessive disorder defined by the absence of one or more of the proteins required for blood clotting. Almost all of one x chromosome in each cell in female mammals becomes inactivated during early embryonic development.

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