BIOL 3450 Chapter Notes - Chapter 15: G Protein–Coupled Receptor, Cgmp-Dependent Protein Kinase, Signal Transduction
Document Summary
Receptors bind only single type of hormone or group of closely related hormones: molecular complementarity ~ between interacting surfaces of receptor and ligand. Protein kinases and phosphatases are employed in many signaling pathways: kinases ~ enzymes that add phosphate groups to specific residues of target proteins, phosphatases ~ remove phosphate groups from specific residues on target proteins. Signal transduction pathways can amplify the effects of extracellular signals. 15. 2 studying cell surface receptors and signal transduction proteins. Dissociation constant is measure of affinity of recetpr for its ligand: kd = [r] [l] / [rl] Hormone analogs are widely used as drugs: agonists ~ mimic function of natural hormone by binding to its receptor and inducing normal cellular response to hormone, antagonists ~ bind to receptor but induce no response. 15. 2 g protein coupled receptors: structure and mechanism. Different g proteins are activated by different gpcrs and in turn regulate different effector.
