BSC 1010 Chapter Notes - Chapter 16: Lac Operon, Lac Repressor, Trp Operon
8 Feb 2017
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Document Summary
Regulatory proteins: any of a group of proteins that modulates the ability of rna polymerase to bind to a promoter & begin. This idea of controlling the access of rna polymerase to a promoter is common to both prokaryotes & eukaryotes, but the details differ. Multicellular organisms (eukaryotes) have been shaped by evolution to be protected from transient changes in their immediate environment. Major groove: the larger of the two grooves in a dna helix, where the paired nucleotides" hydrogen bonds are accessible. Regulatory proteins can recognize & bind to regions in the major groove. Dna-binding motif: a region found in a regulatory protein that is capable of binding to a specific base sequence in dna. A critical part of the protein"s dna-binding domain. Domain is a functionally distinct part of the protein necessary to bind to dna in a sequence-specific manner.
