NBB 302 Chapter Notes - Chapter 14.1: Cytochrome P450, Medical Model, Mesocortical Pathway

• School: Emory University
• Department: Neuroscience & Behavioral Sci
• Course: NBB 302
• Professor: Gillian Hue

Document Summary

Drug addiction: the neurobiology of behavior gone awry -- volkow, li: introduction. Drug addiction diff from drug dependence: addiction: a devo disorder. Increase extracellular [da] in limbic regions (nucleus accumbens nac) Drugs ability to surpass magnitude and duration of fast da increases in nac when triggered by natural reinforces. Cocaine, amphetamine, methamphetamine, ecstasy increase da by inhibiting da reuptake/promoting da release by affecting dat. Stimulate neurons (gaba, glut) that modulate da firing via effects on nicotine, gaba, mu opiate, cannabinoid cb1 receptors. Increases in da related to prediction of reward/salience ---> drug-induced increases in da will motivate further procurement of drug regardless of whether effects of drug are perceived as pleasurable. Facilitate conditioned learning --- neutral stimuli become salient and elicit desire for drug via increase in da. *risk of relapse in presence of enviro of taking drug: da increases by natural reinforces in nac undergo habituations.