BIOSC-116 Chapter Notes - Chapter 1: Mycobacterium Tuberculosis, Silver Stain, Hospital-Acquired Pneumonia
9 Dec 2020
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Has pili, filamentous hemagglutinin, pertussis toxin, adenylate cyclase. Incubation stage, catarrhal stage (mild coughing and sneezing, pt very infectious), paroxysmal stage (explosive cough, whoop during inhalation, treatment not effective once at this stage) Treat with erythromycin, new macrolides, or tmp/smx. Whole cell and acellular vaccines available - u. s. only uses acellular (dtap) Lacks cell walls, has sterols in cell membrane - pleimorphic in shape. Adheres tightly to respiratory epithelium using protein adhesin p1. May cause pharyngitis, acute bronchitis, or pneumonia. Gradual onset followed by sob and non-productive cough. Usually a mild disease - walking pneumonia . Patients present with fever, headache, malaise, sore throat, and cough. Occasionally accompanied by neurologic symptoms, skin rashes, or hemolytic anemia. Can be cultured - eaton - requires sterols for growth. Cold hemagglutinatinins seen in 50% of pts - reversible agglutination at 4 deg celsius. Don"t use anything that affects cell walls b/c it doesn"t have. Chlamydia pneumoniae (chlamydophila pneumoniae) a cell wall.
