PHIL 2130 Chapter Notes - Chapter 4.3: Acetic Acid, Fluorine, Bioavailability
6 May 2020
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I. e . although phenol is a weak acid, picric acid with its three nitro groups that can delocalize the negative charge is a very strong acid: other strong acids. Due to ewg effect of three fluorine atoms. Due to sulfonic acid group and carboxylic acid. Benzyl ring does not significantly increase acidity of a carboxylic acid, because it does not allow charge to be delocalized. Acidic h is attached to a nitrogen atom and the negative charge is stabilized by ew effect of so2 group. Acidic h is attached to a carbon and the and delocalization into oxazole ring. Answer: negative charge remaining after the loss of proton is sufficiently stabilized. charge is stabilized by flanking carbonl groups: which is more acidic- thiophenol or cysteine? vs. Answer: thiophenol is more acidic than cysteine for the same reason that phenol is more acidic than alcohol. Answer: amphetamine is a strong base but the guanidine group of arginine is even more basic.
