PHIL 2130 Chapter Notes - Chapter 2.7: Scopolia Carniolica, Acetylcholinesterase Inhibitor, Pupillary Response
6 May 2020
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Physostigmine reversible cholinesterase inhibitor (indirect agent) inhibits breakdown of. Echothiophate irreversible cholinesterase inhibitor binds serine residue in acetylcholinesterase creating stable phosphoester bond that inactivates enzyme (initially reversible but can aging causes it to become irreversible) Used in the eye to reduce intraocular pressure (glaucoma) Neurodegeneration resulting from loss of cholinergic activity in brain. Contracts ciliary body to allow aqueous homour outflow. Causes some bronchodilation and reduction in secretions. Causes mydriasis (pupillary dilation)/cyclopegia (paralysis of accommodation) Found in atropa belladonna (deadly nightshade) and. Found in hyoscyamus niger (henbane) and scopolia carniolica. Given as aerosol to reduce systemic effects. Was used as muscle relaxant (since been replaced) Curare extract from indigenous plants in south. Used in poison darts for hunting and warfare. Muscle relaxation for surgery without deep anesthesia activate nicotinic receptors constitutively so the neuromuscular endplate cannot recover. Used cosmetically for local muscle relaxation in specific locations (botox), ocular conditions, hemifacial spasms, dystonias, dermatological abnormalities.
