KINE 2011 Chapter Notes - Chapter 5.2: Bone Marrow, Erythropoiesis, Haematopoiesis

• School: York University
• Department: Kinesiology & Health Science
• Course: KINE 2011
• Professor: Ali Abdul Sater

Document Summary

Erythrocytes short life span: rbc are short-lived (12o days) & must be replaced, rbc nonrepairable membrane becomes fragile & prone to rupture, spleen removes old erythrocytes from circulation & destroyed rbcs. Spleen located in upper part of abdomen. Spleen has limited ability to store healthy erythrocytes, serves as reservoir for platelets & contains abundance of lymphocytes- a blood cell. Erythropoiesis: red marrow produces rbcs & is ultimate source of leukocytes & platelets, production of new erythrocytes in bone marrow by process called erythropoiesis, bone marrow is found in internal cavities of bones. In children, most bones are filled with red bone marrow. Erythropoietin b/c o2 transport in blood is erythrocytes primary function, primary stimulus for increased erythrocyte production is reduced o2 delivery: reduce o2 delivery to kidney stimulates kidneys to secrete hormone erythropoietin (epo) into blood. This hormone stimulates erythropoiesis by bone marrow: erythropoieti(cid:374) a(cid:272)ts o(cid:374) u(cid:374)differe(cid:374)tiated ste(cid:373) (cid:272)ells that"re to (cid:271)e(cid:272)o(cid:373)e rbcs, sti(cid:373)ulati(cid:374)g them into mature erythrocytes.