BIOL 3051 Chapter Notes - Chapter 6.1: Tricyclic Antidepressant, Noxious Stimulus, Duloxetine
24 Apr 2020
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Cord: several mediators of descending input to spinal cord, mixed effect depending on receptor activated: 5-ht, dopamine, anti-nociceptive: ne, activation of a2a receptors on primary afferent inhibits n-type. Ca2+ channels & nt release: antidepressants can increase monoamines in spinal cord, ne binds to a2-adrenetic receptor inhibits ca2+ channel opening no nt release. Descending modulation: antidepressants: tricyclic antidepressants (clomipramine, serotonin- norepinephrine reuptake inhibitors (snri). Duloxetine: tca & snri block serotonin & ne transporter, enhance activity of descending inhibitory pathway effects brainstem & spinal cord, may act peripherally to reduce nociceptor activation, tca & snri block alpha 1 adrenergic receptors. This results in elevation of synaptic concentration of these nt, thus enhances neurotransmission. Affective aspects of pain: pain & suffering are subjective, feelings of unpleasant contributes to pain, chronic pain is associated w/co-morbid emotions disorders & cognitive deficits: Affective aspects of pain: some analgesic drugs w/psychological effects may work to reduce effective components of pain:
