BIOL 1000 Chapter Notes - Chapter 8: Senescence, Protein Kinase, S Phase

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Cell cycle regulations- mechanisms that controls mitotic cell cycle. Cell cycle can be arrested at specific checkpoints. Cyclin proteins control action of cell cycle. 3 key checkpoints prevent critical phase from beginning until previous stage is complete. Internal controls create checkpoints to ensure that reactions of one stage are complete before cycle continues: g1/ s checkpoint, determines if cell will procced through cell cycle & divide. Important in production of identical copies of cells. Cyclin & cyclin- dependent kinases are internal controls that directly control cell division. Cyclins & cyclin dependant kinases are internal controls that regulate cell division. Direct regulations of cell cycle involve internal control system on contains proteins called cyclin & enzymes called cyclin dependant kinases (cdks) A cdk is protein kinase which phosphorylates & regulates activity of proteins. Cdk e(cid:374)zy(cid:373)es ae (cid:272)y(cid:272)li(cid:374) depe(cid:374)da(cid:374)t (cid:271)/(cid:272) they"re a(cid:272)ti(cid:448)e o(cid:374)ly (cid:449)he(cid:374) (cid:271)o(cid:374)d to (cid:272)y(cid:272)li(cid:374) (cid:373)ole(cid:272)ules.

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