Biochemistry 2280A Chapter Notes - Chapter 4: Rhodopsin, Hemoglobin, Immunoglobulin Light Chain
Document Summary
Changes to the amino acids in the interior of a protein can change the protein"s 3-d shape and destroy its function. Diversity of antigen-binding sites can be generated by changing only the loops, which is how the wide variety of different antibodies is formed. Many drugs inhibit enzymes: many of the drugs we take to treat or prevent illness work by blocking the activity of a particular enzyme. The catalytic activities of enzymes are often regulated by other. Allosteric enzymes have two or more binding sites that influence one. Phosphorylation can control protein activity by causing a. Covalent modifications also control the location and interaction of. In some cases, the modi cation alters the protein"s conformation; in others, it serves as a docking site for other proteins to attach. This layer of con- trol enables the cell to make optimal use of its proteins, and it allows the cell to respond rapidly to changes in its environment.