BCH210H1 Chapter 26: R26

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Specific toward the side groups or amino acids. Review: enzyme specificity: high degree of specificity, urease, specificity for a functional group, alcohol dehydrogenase (-oh, broader specificity, hexokinase (6-carbon sugars, proteases (specific amino acids) subtilisin is not, esterases non specific. Lysozyme: found in tears & salvia, chew"s up bacterial cell walls, polysaccharides are composed of alternating, held together by glycosidic linkages. The cleft is formed when the protein folds into it"s 3d structure: very unique microenvironment, unless hydrolase it excludes water, ph may vary within the active site, glu35, asp52, key residues: One residue from the polysaccharide (bacterial cell wall) fits into each: has 6 binding pockets: binding pocket. Reading 27: idea of enzymes come together with a substrate as a lock (e) and key (s) model. However, didn"t explain how catalysis occurs, what happens after binding: today, we know that enzymes are very flexible, enzyme adopts the complementary substrate binding region, once it comes into the.