BIOA01H3 Chapter Notes - Chapter 21: Genotype Frequency, Allele Frequency, Centromere

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BIOA01H3 Full Course Notes
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BIOA01H3 Full Course Notes
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Neutral mutations: have little to no impact on the organism. Deleterious mutations: harmful impact on the organism. Advantageous mutations: beneficial impact on the organism can increase in frequency within a population. To understand patterns of genetic variation, we require information about allele frequencies. Early population geneticists relied on observable traits and gel electrophoresis to measure variation. It is not possible to rely on traits because many traits are encoded by a large number of genes and the phenotype is the result of the genotype and environment. Gel electrophoresis: a method used to separate mixtures of dna, rna and proteins according to molecular size this reveals what alleles are present and what their frequencies are. Dna sequencing is the hold standard for measuring genetic variation. Evolution is a change in allele or genotype frequency over time: populations evolve as a whole individuals do not evolve. The hardy-weinberg equilibrium relates allele frequencies and genotype frequencies.

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