MICB 202 Chapter Notes - Chapter Bacterial Disease: Peptidoglycan, Hemolysin, Conjugate Vaccine
Document Summary
Define koch"s postulates and describe situations where they may or may not apply, and define the molecular version of koch" postulates. Koch"s postulates: used to determine whether if there"s a relationship between particular organism and disease. Has been used as a guide to determine cause of many important diseases. Has been used to prove causative relationship between most bacterial pathogens and their respective diseases: suspected pathogenic organisms should be present in all cases of diseases and absent from healthy animals. What if individual carries pathogen but does not get disease: pathogenic organisms should be isolated from infected animals and cultivated in pure culture. What if pathogen is a virus: cells of pure culture of suspected pathogen should cause same disease in healthy animals. What if pathogen causes disease in one species but not another: pathogen should be re-isolated from experimentally infected animals and shown to be same as original pathogen. What if pathogen is a virus: 2 major impediments:
