MICB 202 Chapter Notes - Chapter 2: Internal Ribosome Entry Site, Vpg, Cd155
Document Summary
Topic 2: picornaviruses small rna viruses a diverse group of viruses divided into 5 genera (based on physical properties, serological relatedness, nucleotide sequence) Acid stable (can survive exposure at ph 3 or lower) Sensitive to formaldehyde used to denature virus during vaccine production. Presence of organic matter may protect virus from inactivation resistant to many common laboratory disinfectants (inactivate many other types of viruses) May cause paralytic poliomyelitis (flaccid muscular paralysis due to the death of motor neurons) Still causes endemic infections (afghanistan and pakistan) Outbreak caused by vaccine-derived strains in a few countries. Sodium/potassium ions inside capsid counteract -ve charges on phosphate groups of rna. Infectious virus progeny will be produced if rna is introduced (artificially) into a host cell. 5" e(cid:374)d: vpg (cid:1007)" e(cid:374)d: polya tail lo(cid:374)g u(cid:374)t(cid:396)a(cid:374)slated (cid:396)egio(cid:374) (cid:894)utr(cid:895) at 5" e(cid:374)d a(cid:374)d a sho(cid:396)te(cid:396) utr at (cid:1007)" e(cid:374)d. 5" utr important in translation and packaging of genome into the capsids.
