BIOL273 Chapter Notes - Chapter 18: Fetal Hemoglobin, Hemoglobin, Fick'S Laws Of Diffusion

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Maintaining homeostasis: to avoid hypoxia and hypercapnia, the body must monitor arterial blood composition, oxygen levels, carbon dioxide levels acidosis, maintaining ph. Co2 diffuses from the cells to the plasma of the blood. In the capillaries of the alveoli, co2 has a lower partial pressure than in the plasma, so co2 diffuses from the plasma out to the alveoli. Amount of o2 bound/max bound = % saturation hemoglobin. Oxygen-hemoglobin saturation curve: % hb saturation vs po2, physical factors such as temperature, ph , 2,3-dgp and pco2 affect. Hb"s affinity for o2: shift in binding affinity due to ph is called the bohr effect fetal hemoglobin has different globulin structures, which have a higher affinity for o2. For cl- (hco3 into plasma: hb acts as a buffer. Returns to the rbc"s: removal of co2 (at the lungs) causes h+ to leave the hb which can bind with the newly available hco3.

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