PSYC 2490 Chapter Notes - Chapter 4: Clinical Trial, Single-Nucleotide Polymorphism, Internal Validity

• School: University of Manitoba
• Department: Psychology
• Course: PSYC 2490
• Professor: Janine M.Montgomery

Document Summary

3 methods to uncover whether a genetic predisposition for psychopathology is inherited: 1) comparison of members of a family, 2) comparison of pairs of twins, 3) investigation of adoptees o family method = used to study genetic predisposition among family members. *average number of genes shared by 2 blood relatives is known. 1st degree share 50%, 2nd degree share 25% Index cases/probands = persons with the diagnosis in question o twin method = monozygotic and dizygotic twins are compared. Mz (identical) develop from 1 egg, genetically the same. Dz (fraternal) develop from separate eggs, share 50% genes. When mz concordance is higher than dz concordance, characteristic is heritable o adoptees method = studies children who were adopted and reared apart from their biological parents. Stronger evidence that a disorder is genetic if biological parents and child (who was not raised by bio parents) both have disorder.