MBIO 1010 Chapter Notes - Chapter 27: Erythromycin, Streptomycin, Gonorrhea
6 Dec 2016
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Compounds that kill or control the growth of microorganisms in the host. Selective toxicity: inhibit/kill pathogen but do not harm the host. Two broad categories: synthetic and natural. Growth factor analogs: analog something that is structurally similar to something but has a different function, structurally similar to growth factors but do not function in the cell. Analogs similar to vitamins, amino acis, and other compounds: sulfa drugs: discovered by gerhard domagk in the 1930s. Inhibit growth of bacteria (eg. sulfanilamide) by inhibiting folic acid synthesis and thus nucleic acid synthesis. 27. 23: short form of the molecule (b) is paba: part of vitamin folic acid which is precursor for nucleic acid synthesis. Quinolones: inhibit dna gyrase (eg. ciprofloxacin), prevent dna supercoiling, active against both gram-negative and. Gram-positive bacteria: broad spectrum: effective against wide range of bacteria, eg. gram positive and gram neg, narrow spectrum drug: selectively target one type/ group eg. gram positive.
