PHAR 100 Chapter Notes - Chapter 2: Sulindac, Hydroxyzine, Metoprolol
11 Nov 2016
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Lesson a. 2 drug advertising, drug trials and placebo effects. Understand the techniques and types of drug advertising. Distinguish between a valid and invalid drug trail and the method of progression. Many techniques have been used throughout the years. France, late 19th century, artists were commissioned by pharmaceutical manufacturers to paint colourful posters for advertisement. Prior to 1938 regulation for introducing drugs into therapeutic use were not well defined. 1938: a sulfonamide antibacterial drug dissolved in a solvent was introduced into therapeutics in the usa, it was toxic and killed approx. 100 people lead to the regulatory requirement of a drug toxicity profile. 1962: thalidomide, as prescribed to pregnant women produced fetal malformations lead to the requirement of evidence of the safety and efficacy (effectiveness) of a drug. Administration usa: detailed methodology of the proposed clinical trail in humans must be composed, pharmaceutical manufacturer"s detailed submission is then reviewed carefully by regulatory agencies/scientists.
